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Dr Alessandra Geremia

Dr Alessandra Geremia

George and Susan Brownlee Junior Research Fellow in Biomedical Sciences

I am an academic gastroenterologist with a strong interest in Inflammatory Bowel Disease (IBD). I trained in one of the leading academic centres in Italy at the University of Tor Vergata in Rome and moved to Oxford in 2005 to work on a research fellowship in IBD genetics under the supervision of Professor Derek Jewell. In 2007, I obtained a Research Training Fellowship from the Wellcome Trust to investigate the role of the IL23/IL17 axis in IBD in Professor Fiona Powrie’s laboratory at the Sir William Dunn School of Pathology and then at the Translational Gastroenterology Unit (TGU) in Oxford. This work has led to completion of my DPhil. I have pursued my research interests as an academic clinical lecturer and I have recently started a Wellcome Trust postdoctoral fellowship at the TGU.

Research interests 

•    To elucidate the host-microbiome interaction in patients with IBD and Primary Sclerosing Cholangitis (PSC)
•    To investigate the mucosal and systemic immune responses in patients with IBD
•    To study the role of innate lymphoid cells in the human mucosal immune response and in the pathogenesis of intestinal disorders

Current project

My current research focuses on the characterisation of the immune response and the host-microbiome interaction in patients with PSC and IBD. I am using multi-colour flow cytometry and molecular biology techniques to characterize the mucosal and systemic immune response and evaluate whether specific immune pathways are involved in inflammation and increased cancer risk. Whole-genome shotgun sequencing is being used to evaluate the host-microbial interaction and how microbial metabolites can influence the human immune response.

Recent publications

Geremia A, Biancheri P, Allan P, Corazza GR, Di Sabatino A. Innate and adaptive immunity in inflammatory bowel disease. Autoimmun Rev. 2014;3(1):3-10.

Geremia A & Jewell DP. The IL23/IL17 pathway in Inflammatory Bowel Disease. Exp Rev Gastroenterol Hepatol. 2012;6(2):223-37.

Walker LJ, Kang YH, Smith MO, Tharmalingham H, Ramamurthy N, Fleming VM, Sahgal N, Leslie A, Oo Y, Geremia A, Scriba TJ, Hanekom WA, Lauer GM, Lantz O, Adams DH, Powrie F, Barnes E, Klenerman P. Human MAIT and CD8?? cells develop from a pool of type-17 precommitted CD8+ T cells. Blood. 2012;119(2):422-33.

Geremia A, Arancibia-Carcamo CV, Fleming MPP, Rust N, Singh B, Mortensen NJ, Travis SP, Powrie F. IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease. J Exp Med, 2011;208(6):1127-33.

Guo C, Ahmad T, Beckly J, Cummings JR, Hancock L, Geremia A, Cooney R, Pathan S, Jewell DP. Association of caspase-9 and RUNX3 with inflammatory bowel disease.Tissue Antigens, 2011;77(1):23-9.

Cummings JR, Cooney RM, Clarke G, Beckly J, Geremia A, Pathan S, Hancock L, Guo C, Cardon LR, Jewell DP. The genetics of NOD-like receptors in Crohn's disease. Tissue Antigens. 2010;76(1):48-56.

Cooney R, Cummings JR, Pathan S, Beckly J, Geremia A, Hancock L, Guo C, Morris A, Jewell DP. Association between genetic variants in myosin IXB and Crohn's disease. Inflamm Bowel Dis. 2009;15(7):1014-21.

Hancock L, Beckly J, Geremia A, Cooney R, Cummings F, Pathan S, Guo C, Warren BF, Mortensen N, Ahmad T, Jewell D. Clinical and molecular characteristics of isolated colonic Crohn's disease. Inflamm Bowel Dis. 2008;14(12):1667-77.

Beckly JB, Hancock L, Geremia A, Cummings JR, Morris A, Cooney R, Pathan S, Guo C, Jewell DP. Two-stage candidate gene study of chromosome 3p demonstrates an association between nonsynonymous variants in the MST1R gene and Crohn's disease. Inflamm Bowel Dis. 2008;14(4):500-07.

Cummings JR, Ahmad T, Geremia A, Beckly J, Cooney R, Hancock L, Pathan S, Guo C, Cardon LR, Jewell DP. Contribution of the novel inflammatory bowel disease gene IL23R to disease susceptibility and phenotype. Inflamm Bowel Dis. 2007;13(9):1063-68.

Cummings JR, Cooney R, Pathan S, Anderson CA, Barrett JC, Beckly J, Geremia A, Hancock L, Guo C, Ahmad T, Cardon LR, Jewell DP. Confirmation of the role of ATG16L1 as a Crohn's disease susceptibility gene. Inflamm Bowel Dis. 2007;13(8):941-16.


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